Genomics

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The type of phagocytic receptor modulates gene expression and phagosome functions in macrophages


ABSTRACT: The receptors engaged during phagocytic particle uptake determine the signaling events that occur during phagosome formation and maturation. However, pathogens generally have multiple ligands, making it difficult to dissect the roles of individual receptors in these processes. Here, we used latex beads coupled to single ligands, focusing on IgG, mannan, LPS and avidin, and monitored phagocytic uptake rates, phago-lysosomal fusion events, macrophage gene expression and the proteomic composition of isolated phagosomes. The pattern of gene expression and the protein composition of isolated phagosomes showed that each bead ligand altered a distinct pattern of genes and led to a different composition of phagosomes. These data argue that activation of each receptor initiates a specific signature of signaling events that last many hours and influences several phagocytosis functions.

ORGANISM(S): Mus musculus

PROVIDER: GSE17761 | GEO | 2009/09/10

SECONDARY ACCESSION(S): PRJNA118305

REPOSITORIES: GEO

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