Inducible degradation of the Mediator subunit Med19 reveals a dedicated role in the regulation of developmental genes expression

ABSTRACT: In the Drosophila wing imaginal disc, by using a inductible degradable version of Med19 degradation with RNAseq, we got access to the early consequences of Med19 depletion on gene expression. We showed that less than a quarter of the genes expressed in the wing disc were deregulated after Med19 loss. Strikingly, these genes exhibit a spatio-temporal expression pattern like transcription factors or Notch responsive genes that reveals Med19 dedicated role in the regulation of developmental gene transcription.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE178125 | GEO | 2023/12/31

REPOSITORIES: GEO