Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 4000 (Mus musculus)
ORGANISM(S): Mus musculus
SUBMITTER: Jianmei Wu Leavenworth
PROVIDER: GSE178132 | GEO | 2021-11-24
REPOSITORIES: GEO
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GSE178132_G-J_normalized_counts.csv.gz | Csv | |||
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Dixon Michael L ML Luo Lin L Ghosh Sadashib S Grimes Jeffrey M JM Leavenworth Jonathan D JD Leavenworth Jianmei W JW
Molecular cancer 20211120 1
<h4>Background</h4>Accumulation of Foxp3<sup>+</sup> regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the transcription factor Blimp1. However, the specific impact of these Blimp1<sup>+</sup> Treg cells and their follicular regulatory T (T<sub>FR</sub>) cell subset on tumor and the underlying mechani ...[more]