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Whole transcriptome miRNA profiling of Coronavirus Disease 2019 (COVID-19) patient plasma.

ABSTRACT: The purpose of this study was to identify miRNAs that were dysregulated after the onset of COVID-19 and thus potentially be used for risk stratification (i.e., mortality). Therefore, we conducted a multi-center, retrospective longitudinal cohort study enrolling 142 patients with laboratory-confirmed SARS-CoV-2 infection who presented to two Canadian hospitals from May 2020 – December 2020 along with a cohort of 27 SARS-CoV-2 patients with mild upper respiratory tract symptoms and 69 SARS-CoV-2-negative patients from the ICU. Blood was biobanked from SARS-CoV-2 positive patients in the emergency department (mild), ward (moderate) or intensive care unit (severe). Assessment of miRNA expression and co-regulatory network generation revealed significant transcriptome dyregulation in pateints with severe COVID-19 that was largely different from SARS-CoV-2 negative patients in the ICU.

ORGANISM(S): Homo sapiens

PROVIDER: GSE178246 | GEO | 2022/04/08

REPOSITORIES: GEO

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mRNA profiling in pooled human umbilical vein endothelial cells stimulated with Coronavirus Disease 2019 (COVID-19) patient plasma

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2022-03-01 | E-MTAB-10970 | biostudies-arrayexpress

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SARS-CoV-2 RNAemia and proteomic biomarker trajectory inform prognostication in COVID-19 patients admitted to intensive care

2021-04-26 | PXD024026 | Pride

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