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Modulation of macrophage polarization by HMB [macrophage]

ABSTRACT: to determine whether hydroxymethyl butyrate alters macrophage polarization bone marrow derived macrophages were treated with HMB alone or in combination with LPS for 48h

ORGANISM(S): Mus musculus

PROVIDER: GSE178475 | GEO | 2021/12/29

REPOSITORIES: GEO

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Modulation of macrophage polarization by HMB [muscle]

Project description:to determine whether hydroxymethyl butyrate alters PDAC response to anti-PD1 therapy, mice bearing PANC02 tumors were treated with anti-PD1 with or without HMB supplementation, gastroc mucsle was isolated from ctrl and HMB groups and analysed by microarray for HMB induced differences in gene expression

2021-12-29 | GSE178476 | GEO

Modulation of macrophage polarization by HMB [tumor]

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Modulation of macrophage polarization by HMB

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Project description:Modulation of macrophage polarization by HMB [macrophage]

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Modulation of macrophage polarization by HMB [muscle]

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Modulation of macrophage polarization by HMB

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-12-29 | GSE178478 | GEO

Effects of a nutritional supplement in older individuals subject to ten days of complete bed rest.

Project description:Older individuals subjected to complete bed rest for 10 days were randomized to a complete nutritional supplement with or without hydroxymethyl butyrate (HMB). Muscle biopsies from the vastus lateralis were obtained immediately prior and at the conclusion of the bed rest. RNA-sequencing was performed to determine the gene expression changes associated with bed rest. Marked decrease in the expression of genes associated with mitochondrial energy metabolism including fatty acid oxidation, TCA cycle and the electron transport chain was observed with bed rest. These effects were partly mitigated in the subjects provided the nutritional supplement with HMB.

2019-11-01 | GSE130722 | GEO

Proteomic signature of environmental oxygen tension modulation of human macrophage polarization and functions

Project description:Macrophages are innate immune cells characterized by their plasticity and their ability to react to various environmental stimuli. These cells are involved in a multiple number of tissular functions in homeostasis and pathological contexts. According to their environment these cells could be polarized toward different states of activation which determine their functional orientation. A large part of the macrophage biology field is devoted to better define what polarizations are, from a molecular point of view. It is now accepted that a multidimensional model of polarization is needed to grasp the broad phenotype repertoire depending on various environmental signals. Oxygen tension is one of these tissular environmental parameters. We designed this study to obtain a proteomic signature of various polarizations in human monocytes derived macrophages. We also seek to explore how environmental oxygen tension varying from an atmospheric composition (18.6% O2) to a “tissular normoxia” (3% O2) could modify our classification of macrophages’ polarization. We have obtained various polarization specific proteins and oxygen sensors for human macrophages. One example is arachidonate 15-lipoxygenase (ALOX15) which is a IL4/IL13 polarization specific proteins up regulated under low oxygen exposure associated to an increase of the phagocytosis rate of apoptotic cells. These results illustrate the necessity to take into account physicochemical parameters like oxygen when macrophage polarization is studied to correctly assess their functions in tissues.

2017-09-11 | PXD006354 | Pride

Expression data from differentiating equine satellite cells (ESC) culture incubated with HMB and exposed to hydrogen peroxide

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2018-04-03 | GSE93025 | GEO

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