Genomics

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Genome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells


ABSTRACT: STAT6 is a major transcription factor driving the polarization of Th2 cells in response to IL-4. STAT6 is phosphorylated by Jak1 and Jak3 kinases at the IL-4 receptor, after which phosphorylated STAT6 forms a homodimer and translocates into the nucleus. There STAT6 binds to specific DNA sequences, regulating the transcription of its target genes. Here we have analyzed on a genome wide level the STAT6 binding sites, after 1h and 4h of IL-4 induction, in naive human CD4+ T cells. Keywords: SRA

ORGANISM(S): Homo sapiens

PROVIDER: GSE17850 | GEO | 2010/06/25

SECONDARY ACCESSION(S): PRJNA123545

REPOSITORIES: GEO

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