FoxM1-Retinoblastoma Interaction Induces Tumor Microenvironment That Drives Metastasis

ABSTRACT: A mouse strain expressing an Rb-binding deficient mutant of FoxM1, FoxM1 DD, develops PyMT-driven mammary tumors that are deficient in metastasis. Single-cell RNA-Seq analyses revealed altered tumor microenvironment (TME). Unlike the FoxM1 +/+ tumors, the FoxM1 DD/DD tumors lack tumor-infiltrating cells, resulting from a deficiency in the tumor cell-populations that express factors necessary for their recruitment. Furthermore, FoxM1 DD/DD tumors contain fewer mammary cancer stem/progenitor cells, but more differentiated tumor cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE178612 | GEO | 2024/06/20

REPOSITORIES: GEO