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The role of Aspergillus fumigatus SmiA transcription factor in the miltefosine resistance

ABSTRACT: By searching for new drugs against fungal pathogens, we found that miltefosine is active against Aspergillus fumigatus clinical isolates. A library of transcription factors (TF) null mutants was then challenged with this drug and we discovered a novel TF that confers resistance to miltefonise, named here SmiA. By using ChIP-seq, we searched for SmiA targets upon miltefosine treatment.

ORGANISM(S): Aspergillus fumigatus

PROVIDER: GSE178664 | GEO | 2021/08/23

REPOSITORIES: GEO

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