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Transcriptomics analysis and redox-dependent metabolic rewiring in triple-negative breast cancer cells

ABSTRACT: Glucose metabolism toward aerobic glycolysis provides cancer cells with a rapid generation of pyruvate, ATP, and NADH. CtPB2, an NADH-dependent transcriptional co-regulator, has been proposed to work as an NADH sensor, linking metabolism to transcriptional reprogramming. Here we described how the down-regulation of CtBP2 strongly reduces cell proliferation in triple negative breast cancer (BC) cell line, by modulating several intracellular pathways also through gene expression modification. Our data highlight the critical role of NADH in controlling energetic and anabolic demands in cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE178748 | GEO | 2021/10/27

REPOSITORIES: GEO

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