Adaptive and non-adaptive gene expression changes in prostate cancer during androgen deprivation

ABSTRACT: In this study long-term cell cultures were used to model castration resistant prostate cancer (CRPC) and to understand the cellular mechanisms leading to CRPC. Study included a testosterone-dependent cell line (VCaP-T) and more antiandrogen resistant and AR upregulating cell line adapted to grow in low testosterone (VCaP-CT). They were used uncover persistent and adaptive responses to testosterone level. RNA was sequenced to study AR-regulated genes. To evaluate their significance for CRPC growth, we compared which of them were adaptive i.e., restored expression level in VCaP-CT. The goal was to identify novel risk genes that could be possibly used as biomarkers or therapeutic targets in the future.

ORGANISM(S): Homo sapiens

PROVIDER: GSE178864 | GEO | 2023/02/01

REPOSITORIES: GEO