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Mouse Embryonic Stem Cell E14Tg2A.4 BMP2 Responses

ABSTRACT: Study was carried out to investigates the acute responses of mouse ES cells to BMP-2.

ORGANISM(S): Mus musculus

PROVIDER: GSE17896 | GEO | 2010/08/15

SECONDARY ACCESSION(S): PRJNA120085

REPOSITORIES: GEO

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Mouse Embryonic Stem Cell E14Tg2A.4 BMP2 Responses

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Mus musculus isolate:ES-E14TG2a

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Matrix metalloproteinase-3 mediates cardiac differentiation of mouse embryonic stem cells

Project description:Recently, it was shown that the Bmp antagonist Noggin could strongly induce cardiomyocyte differentiation by transient treatment of undifferentiated ES cells. In order to determine how Noggin may induce cardiac differentiation, we compared differentially expressed genes during Noggin treatment of ES cells using microarray analysis and found that matrix metalloproteinase (Mmp)-3 is the only gene whose expression is increased by Noggin treatment. Keywords: embryonic stem cells, cardiac differentiation, matrix metalloproteinase-3, Noggin

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