Ppara and fatty acid oxidation coordinate hepatic transcriptional architecture (ChIP-Seq)

ABSTRACT: Mice harboring a liver-specific carnitine palmityltransferase 2 (Cpt2) knockout exhibit drastic lipid accumulation following a 24hr fast. Crossing Cpt2L-/- mice with Pparα-/- mice provides a model to drive ligand-activated Pparα signaling in liver. We use this to investigate unique patterns of Pparα target gene transcription and demonstrate the requirement for ligand-activated Pparα in maintaining transcriptionally permissive genomic architecture in liver including regulation of promoters and enhancer elements during periods of acute nutrient deprivation.

ORGANISM(S): Mus musculus

PROVIDER: GSE179052 | GEO | 2021/06/29

REPOSITORIES: GEO