Next Generation Sequencing Quantitative Analysis of PCB-exposed and Sham-exposed Rats Liver, Brain, Thymus and Spleen Transcriptomes

ABSTRACT: Our goal was to investigate the transcriptomes changes on rats liver, brain, thymus, and spleen after exposure to an indoor school air mixture (SAM+) of polychlorinated biphenyls (PCBs). Female Sprague-Dawley rats were exposed to SAM+ at a concentration of 45.5±5.9 µg/m^3 Σ209PCB or filtered air (sham group) 4 h/day, 6 days/week for 13 weeks using nose-only exposure systems. Twenty-four hours after the final exposure, rats were euthanized by carbon dioxide inhalation followed by cervical dislocation. Cardiac blood was collected and organs were excised and stored at -80 °C until analysis.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE179117 | GEO | 2021/06/30

REPOSITORIES: GEO