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A Novel platform for single-cell RNA-sequencing and its application in genome medicine [icell8]

ABSTRACT: we describe the utility of this novel platform in the field of genome medicine using a full-length approach to evaluate the relationship between transcriptional and mutational heterogeneity on single cells in dermal fibroblasts derived from patients with Hutchinson-Gilford progeria syndrome (HGPS)

ORGANISM(S): Homo sapiens

PROVIDER: GSE179204 | GEO | 2022/03/31

REPOSITORIES: GEO

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Dataset's files

Source:

			Action	DRS
		Other
	GSE179204_RAW.tar	Raw
	GSE179204_gene_info.csv.gz	Csv
	GSE179204_icell8-demultiplexed.txt.gz	Txt
	filelist.txt	Txt

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A Novel platform for single-cell RNA-sequencing and its application in genome medicine [bulk]

Project description:we describe the utility of this novel platform in the field of genome medicine using a full-length approach to evaluate the relationship between transcriptional and mutational heterogeneity on single cells in dermal fibroblasts derived from patients with Hutchinson-Gilford progeria syndrome (HGPS)

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A Novel platform for single-cell RNA-sequencing and its application in genome medicine [cellenone]

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Project description:Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by progerin accumulation. However, the mechanism of how progerin causes cell defects is unclear in HGPS cells. To further investigate the possible mechanism, we used Flag-tagged progerin as bait in mass spectrometry to survey the possible regulatory factors.

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SILAC pulse labeling in HGPS fibroblasts - HGPS samples

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SILAC analysis of relative protein abundance in cytosol - AG3258 and AG11498

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