Transcriptomics,Genomics

Dataset Information

31

Effects of Hfe-/- and dietary iron overload on gene expression in the liver and duodenum of mice


ABSTRACT: Iron is an essential trace element whose absorption is usually tightly regulated in the duodenum. HFE-related hereditary hemochromatosis (HH) is characterized by abnormally low expression of the iron-regulatory hormone, hepcidin, which results in increased iron absorption. The liver is crucial for iron homeostasis as it is the main production site of hepcidin. The aim of this study was to explore and compare the genome-wide transcriptome response to Hfe deficiency and dietary iron overload in murine liver and duodenum. Overall design: C57BL/6 male mice were used following the next scheme: 3 Hfe knockout mice and 2 wild type mice as their controls; 3 mice with dietary iron overload and 2 mice fed a standard diet as their controls. 2 tissues were analyzed from all the described mice, liver and duodenum. As an exception, the duodenum samples of only 2 Hfe knockout mice, instead of 3, were used. This makes a total of 19 samples: 10 liver samples and 9 duodenum samples.

INSTRUMENT(S): Illumina mouse-6 v1.1 expression beadchip

SUBMITTER: Alejandra Rodriguez-Martinez  

PROVIDER: GSE17969 | GEO | 2009-09-05

SECONDARY ACCESSION(S): PRJNA119943

REPOSITORIES: GEO

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Publications

Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum.

Rodriguez Alejandra A   Luukkaala Tiina T   Fleming Robert E RE   Britton Robert S RS   Bacon Bruce R BR   Parkkila Seppo S  

PloS one 20090929 9


Iron is an essential trace element whose absorption is usually tightly regulated in the duodenum. HFE-related hereditary hemochromatosis (HH) is characterized by abnormally low expression of the iron-regulatory hormone, hepcidin, which results in increased iron absorption. The liver is crucial for iron homeostasis as it is the main production site of hepcidin. The aim of this study was to explore and compare the genome-wide transcriptome response to Hfe deficiency and dietary iron overload in mu  ...[more]

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