Dual roles for piRNAs in promoting and preventing transgenerational gene silencing in C. elegans

ABSTRACT: To explore the roles of piRNAs in regulating 22G-RNA production and transgenerational gene silencing, we used RNA-seq to assess changes in small RNA and mRNA levels in piwi/prg-1 and mutator mutants at an early generation and again at a late generation. We identified that in the absence of piRNAs, many genes gain 22G-RNAs which in turn guide transgenerational gene silencing.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE179811 | GEO | 2021/07/10

REPOSITORIES: GEO