Genomics

Dataset Information

0

Transcriptomic and proteomic analyses of colon inflammation in interleukin-10 gene-deficient mice


ABSTRACT: A total of 30 male IL10-/- (B6.129P2-Il10/J) and 30 male C57 control (C57BL/6J) mice were obtained from The Jackson Laboratory (Bar Harbor, Maine, USA). All mice were between 28 and 35 days of age at the start of the study. For convenience and consistency in reporting, their age was defined as 35 days or 5 weeks of age. The mice were housed individually in standard shoebox size cages containing untreated wood shavings and maintained in an air-conditioned animal room with a 12-h light-dark cycle. Animals had free access to water and were fed an AIN-76A standard powder diet prepared in-house. This study was approved by the AgResearch Ruakura Animal Ethics Committee in Hamilton, New Zealand according to the Animal Protection Act (1960) and Animal Protection Regulations (1987) and amendments. Four days after arrival, all mice were inoculated orally with a mixture of Enterococcus faecalis strains and bacteria commonly found in the intestinal lumen to obtain a more consistent and reproducible intestinal inflammation. Mice were randomly assigned to five sampling groups (7, 8.5, 10, 12 and 14 weeks of age).

ORGANISM(S): Mus musculus

PROVIDER: GSE17990 | GEO | 2009/09/10

SECONDARY ACCESSION(S): PRJNA120027

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-17990 | biostudies-arrayexpress
2008-07-10 | GSE12028 | GEO
| E-GEOD-39859 | biostudies-arrayexpress
| E-GEOD-12028 | biostudies-arrayexpress
2020-08-04 | GSE155626 | GEO
| E-GEOD-59956 | biostudies-arrayexpress
2013-03-01 | GSE39859 | GEO
2017-10-27 | GSE104255 | GEO
| E-GEOD-13819 | biostudies-arrayexpress
| E-GEOD-25095 | biostudies-arrayexpress