N3 induced reprogramming and ShWT1 knock-down in DSRCT cell lines

ABSTRACT: The object of this study is to identify the molecular signature underlying the therapeutic potential of N3-induced growth arrest in Desmoplastic Small Round Cell Tumor (DSRCT). The molecular hallmark of DSRCT is the EWS-WT1 fusion protein formed by chromosomal translocations found in DSRCT. The N-terminal transactivation domain of EWS is fused to the C-terminal DNA binding domain of WT1, creating an oncogenic transcription factor. We have recently discovered that addition of N3 supplement to growing DSRCT cells leads to a rapid cessation of cell growth.

ORGANISM(S): Homo sapiens

PROVIDER: GSE180031 | GEO | 2022/04/14

REPOSITORIES: GEO