ATAC-seq analysis of radioresistant/sensitive cells in oral cancer

ABSTRACT: ATAC-seq identified a total 80,764 peaks in radioresistant cells (HSC-3;0Gy, 8Gy) and radiosensitive cells (KOSC-2;0Gy, 8Gy) (n=2). 1273 peaks were shown as chromatin opened regions and 839 peaks were shown as chromatin closed regions in HSC-3 8Gy compared to HSC-3 0Gy. 285 peaks were shown as chromatin opened regions and 1760 peaks were shown as chromatin closed regions in KOSC-2 8Gy compared to KOSC-2 0Gy. 3804 peaks were shown as chromatin opened regions and 1929 peaks were shown as chromatin closed regions in KOSC-2 0Gy compared to HSC-3 0Gy. By hierarchical clustering analysis and heatmap, the difference of chromatin accessibility in KOSC-2 was lower than HSC-3.

ORGANISM(S): Homo sapiens

PROVIDER: GSE180074 | GEO | 2022/01/01

REPOSITORIES: GEO