Time-series transcriptomic analysis of murine colon undergoing AOM-DSS tumorigenesis with and without LXR activation

ABSTRACT: To unbiasedly characterize the differentially expressed genes and pathways during colorectal cancer initiation and progression, we performed a time-series transcriptional analysis of total colonic tissue during the course of azoxymethane (AOM)-dextran sodium sulfate (DSS) induced colorectal cancer from mice receiving standard (chow) diet. Additionally, to understand the role of LXR activation during AOM-DSS tumorigenesis, we also collected colonic tissues from mice fed with GW3965 diet.

ORGANISM(S): Mus musculus

PROVIDER: GSE180078 | GEO | 2024/07/19

REPOSITORIES: GEO