Transcriptomic analyis of follicular and marginal zone B cells after inducible Tsc1 deletion

ABSTRACT: Observations that ongoing mTORC1 activity drives plasma cell poise in MZ B cells we rationed that enforcing mTORC1 activity on mature follicular B cells by inducible B cell specific Tsc1 deletion would confer plasma cell differention poise on follicular B cells. We therefore performed RNA-seq on follicular and marginal zone B cells from Tsc1F.hCD20-TamCre mice after 4 weeks tamoxifen treatment to examine transcriptional markers of plasma cell differentiation poise.

ORGANISM(S): Mus musculus

PROVIDER: GSE180173 | GEO | 2021/07/22

REPOSITORIES: GEO