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Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states

ABSTRACT: In this study, we introduce BacDrop, a bacterial droplet-based high throughput scRNA-seq technology that can be applied to large cell numbers. We applied BacDrop to study Klebsiella pneumoniae clinical isolates and elucidated their critical, genome-wide heterogeneity in the absence and presence of antibiotic perturbations.

ORGANISM(S): Enterococcus faecalis Escherichia coli Klebsiella pneumoniae Pseudomonas aeruginosa

PROVIDER: GSE180237 | GEO | 2023/01/27

REPOSITORIES: GEO

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