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Gene expression analysis in complex canine chronic cutaneous lupus erythematosus (CCLE)

ABSTRACT: We performed a comparative immunology case study of client-owned dogs to determine if immune and skin gene expression profiles in spontaneous canine chronic cutaneous lupus erythematosus (CCLE) with concomitant systemic autoimmunity mirror those observed in human CCLE.

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE180276 | GEO | 2022/02/11

REPOSITORIES: GEO

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Gene expression analysis in canine discoid/chronic lupus erythematosus, mucocutaneous lupus erythematosus and lupoid drug reaction

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Gene expression analysis in canine Vogt-Koyanagi-Harada/uveodermatologic syndrome and vitiligo

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Gene expression analysis in canine diffuse large B cell lymphoma (DLBCL)

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Gene expression analysis in complex canine chronic cutaneous lupus erythematosus (CCLE)

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SNP and Expression data from the Cancer Cell Line Encyclopedia (CCLE)

Project description:This SuperSeries is composed of the following subset Series: GSE36133: Expression data from the Cancer Cell Line Encyclopedia (CCLE) GSE36138: SNP array data from the Cancer Cell Line Encyclopedia (CCLE) Refer to individual Series

2012-03-20 | E-GEOD-36139 | biostudies-arrayexpress

Proteomic characterization of canine gastric fluid by liquid chromatography mass spectrometry (LCMS) for development of protein biomarkers in regurgitation, vomiting, and cough

Project description:Reflux and aspiration in people cause and exacerbate respiratory diseases in the absence of gastrointestinal (GI) signs. Protein biomarkers in humans detect extra-esophageal reflux (EER) from oropharyngeal (OP) and bronchoalveloar lavage samples. Reflux likely contributes to respiratory disease in dogs. The objectives of this study were to analyze the canine gastric fluid (GF) proteome and compare this to the OP proteome in normal, vomiting/regurgitating and coughing dogs to identify biomarkers for EER/aspiration. Twenty-three client-owned dogs were enrolled. Canine GF samples (n=5) and OP swabs in normal (n=6), vomiting/regurgitating (n=7), and coughing (n=5) dogs were within 2 weeks of sample collection. Protein digests were analyzed by liquid chromatography mass spectrometry (LCMS). Differential abundance (DA) of proteins between groups was evaluated by Fisher Exact test with p< 0.0004 significance level after correction for multiple comparisons. DA was found between all groups (P <0.0001): GF versus normal (n=130 proteins), cough versus normal (n=22 proteins), vomiting/regurgitating versus normal (n=20 proteins). Protein abundance was highly variable between dogs. Gastrointestinal-specific proteins were found in OP swabs from vomiting/regurgitating and coughing dogs but not healthy dogs. In conclusion, the proteomic composition of the OP varies between health and disease. Presence of gastrointestinal-specific proteins in OP of coughing dogs may suggest reflux and/or aspiration as contributing factors. Variable protein abundance warrants investigation into biomarker panels.

2021-04-12 | MSV000087178 | MassIVE

Expression data from the Cancer Cell Line Encyclopedia (CCLE)

Project description:The Cancer Cell Line Encyclopedia (CCLE) project is a collaboration between the Broad Institute, the Novartis Institutes for Biomedical Research and the Genomics Novartis Foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models It consists of a compilation of gene expression, chromosomal copy number, and massively parallel sequencing data from nearly 1,000 human cancer cell lines. All raw and processed data are available through an integrated portal on www.broadinstitute.org/ccle

2012-03-20 | GSE36133 | GEO

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