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Nucleus Type-Specific DNA Methylomics Reveals Epigenetic "Memory" of Prior Adaptation in Skeletal Muscle

ABSTRACT: Using a mouse model of conditional and inducible in vivo fluorescent myonuclear labeling (HSA-GFP), sorting purification of nuclei, low-input reduced representation bisulfite sequencing (RRBS), and a translatable and reversible model of exercise (progressive weighted wheel running, PoWeR), we provide the first nucleus type-specific epigenetic information on skeletal muscle adaptation and detraining.

ORGANISM(S): Mus musculus

PROVIDER: GSE180433 | GEO | 2021/12/08

REPOSITORIES: GEO

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Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle

Project description:Using a mouse model of conditional and inducible in vivo fluorescent myonuclear labeling (HSA-GFP), sorting purification of nuclei, low-input reduced representation bisulfite sequencing (RRBS), and a translatable and reversible model of exercise (progressive weighted wheel running, PoWeR), we provide the first nucleus type-specific epigenetic information on skeletal muscle adaptation and detraining along with whole muscle transcriptomics.

2021-12-08 | GSE180877 | GEO

Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise in mice [NovoGene]

Project description:Aged mice (22-24 mo) underwent Progressive weighted wheel running (PoWeR) for 8 weeks. RNA-seq on soleus and plantaris muscles was conducted on untrained and PoWeR trained mice. RNA from soleus and plantaris of young mice (4-6 months old) was used as a comparator (Englund et al. 2021 Function)

2022-12-01 | GSE198652 | GEO

Aerobic Exercise Improves Molecular and Functional Deficits in A Murine Model of Facioscapulohumeral Muscular Dystrophy

Project description:We investigated the effects of six weeks of voluntary wheel running in heterozygous B6(Cg)-Gt(ROSA)26Sortm1.1(DUX4*)Plj/J (FLExDUX4) mouse model of Facioscapulohumeral Muscular Dystrophy (FSHD) and their wild type (WT) littermates to characterize the structural/functional adaptations to voluntary wheel running and their molecular foundations using RNA sequencing

2023-12-01 | GSE233340 | GEO

Effects of wheel running exercise and myostatin depletion on skeletal muscle gene expression in mice

Project description:This SuperSeries is composed of the following subset Series: GSE31839: Effect of wheel running exercise and myostatin depletion on gene expression in triceps brachii muscles of mice GSE31843: Effect of wheel running exercise on gene expression in skeletal muscles of mice Refer to individual Series

2011-09-02 | E-GEOD-31844 | biostudies-arrayexpress

Effect of wheel running exercise on gene expression in skeletal muscles of mice

Project description:This analysis was done to determine which muscle group has the most skeletal muscle transcriptional reponses to wheel running activity. Seven male mice with C57BL/6 genetic background were placed individually in cages with running wheels and allowed free access to the wheels 24 hr per day. Access to running wheels began when the mice were 6 months old, and continued for 12 weeks. The morning after the night of running, the mice were euthanized and several muscle groups were snap froze in liquid nitrogen to preserve RNA. The same muscle groups were collected from three age-matched "sedentary" mice that were housed in ordinary cages that did not permit sustained running. For each muscle group, separate pools of polyadenylated RNA from the sedentary and wheel-running mice were prepared for deep sequencing of cDNA with the SOLiD 3 platform. Four muscle groups were examined (quadriceps femoris; gastrocnemius/plantaris; tibialis anterior; triceps brachii). For each muscle, RNA was pooled from 3 sedentary or 7 wheel-running mice (8 pools total).

2011-09-03 | E-GEOD-31843 | biostudies-arrayexpress

Effects of voluntary exercise in rat aorta

Project description:Effects of voluntary exercise in rat aorta. Spontaneously hypertensive rats (SHR) performed 5 weeks of voluntary exercise (wheel-cage running). Aortic tissue was collected and samples were pooled (3 aortae/chip). Aortae from running rats were compared to aortae from non-running rats. Keywords: parallel sample

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Transcription profiling of rat aorta samples from rats undergoing voluntary exercise

2007-10-08 | E-GEOD-2418 | biostudies-arrayexpress

Effect of wheel running exercise on gene expression in skeletal muscles of mice

2011-09-03 | GSE31843 | GEO

Analysis of SAMP8 and SAMR1 mice after an exercise intervention

Project description:Microarrays have been used to analyze the effect of voluntary wheel running in the SAMP8 mice using the SAMR1 mouse strain as control.

2012-03-20 | GSE36571 | GEO

Analysis of brain cortices of SAMP8 and SAMR1 mice after an exercise intervention

Project description:Microarrays has been used to analyze the effect of voluntary wheel running in the SAMP8 mice using the SAMR1 mouse strain as control.

2012-06-05 | GSE38465 | GEO

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