Functional redundancy of iron acquisition systems is required for Proteus mirabilis pathogenesis during UTI

ABSTRACT: Proteus mirabilis is a primary cause of complicated urinary tract infections (UTI). Surprisingly, iron acquisition systems have been poorly characterized in this uropathogen despite the urinary tract being iron-limited. In this report the transcriptome of strain HI4320, cultured under iron limitation, was examined using microarray analysis. Of genes upregulated at least 2-fold, 45 were statistically significant and comprise 21 putative iron-regulated systems. Two of these systems, PMI0229-0239 and PMI2596-2605, are organized in operons and appear to encode siderophore biosynthesis genes.

ORGANISM(S): Proteus mirabilis HI4320

PROVIDER: GSE18051 | GEO | 2010/09/09

SECONDARY ACCESSION(S): PRJNA119307

REPOSITORIES: GEO