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Expression data of murine T-ALL OT-1 (Tot-1si) with early expression of mature alphabeta TCR

ABSTRACT: In mice and humans, an immature CD4-CD8- double negative (DN) thymocyte subset expresses early, mature αβTCR. These early αβTCR+ DN (EADN) cells are susceptible to leukemogenesis in both species. Using the OT-1 TCR transgenic system to model EADN-stage αβ TCR expression, we found that EADN cells show coreceptor-independent reactivity to MHC, and their TCR:MHC dependent signals can drive T-ALL transformation. We generated gene expression data from OT-1 leukemic cells and assessed their developmental stage by comparing to wild-type thymocyte subsets.

ORGANISM(S): Mus musculus

PROVIDER: GSE180556 | GEO | 2022/06/28

REPOSITORIES: GEO

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Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation

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