Similar Datasets
Project description:Genomic imprinting resulted by asymmetric epigenome of parents is a conserved phenomenon restricting biased expression of genes on two alleles. Disorder of imprinting can cause severe defects and diseases. In mouse and human, most of imprinted genes are expressed in species-specific and tissue-specific style. Here, rhesus monkeys as non-human primates are used to investigate primate genomic imprinting. We got a novel candidate canonical imprinted genes list in genome-wide by integrated analysis of allele-specific DNase I hypersensitive sites, differential expressed genes and differential DNA methylation. Further analysis revealed that both DNA methylation and H3K27me3 have an effect on the expression of imprinted genes. Consistent with human, analysis of H3K27me3 showed that H3K27me3 undergoes reprogramming in pre-implantation. Thus, our data provides a genome-wide view of genomic imprinting in non-human primates and sheds light on the further understanding of epigenetic programming process of monkey.
2025-12-22 | GSE180571 | GEO
Project description:Genomic imprinting resulted by asymmetric epigenome of parents is a conserved phenomenon restricting biased expression of genes on two alleles. Disorder of imprinting can cause severe defects and diseases. In mouse and human, most of imprinted genes are expressed in species-specific and tissue-specific style. Here, rhesus monkeys as non-human primates are used to investigate primate genomic imprinting. We got a novel candidate canonical imprinted genes list in genome-wide by integrated analysis of allele-specific DNase I hypersensitive sites, differential expressed genes and differential DNA methylation. Further analysis revealed that both DNA methylation and H3K27me3 have an effect on the expression of imprinted genes. Consistent with human, analysis of H3K27me3 showed that H3K27me3 undergoes reprogramming in pre-implantation. Thus, our data provides a genome-wide view of genomic imprinting in non-human primates and sheds light on the further understanding of epigenetic programming process of monkey.
2025-12-22 | GSE180572 | GEO
Project description:Genomic imprinting resulted by asymmetric epigenome of parents is a conserved phenomenon restricting biased expression of genes on two alleles. Disorder of imprinting can cause severe defects and diseases. In mouse and human, most of imprinted genes are expressed in species-specific and tissue-specific style. Here, rhesus monkeys as non-human primates are used to investigate primate genomic imprinting. We got a novel candidate canonical imprinted genes list in genome-wide by integrated analysis of allele-specific DNase I hypersensitive sites, differential expressed genes and differential DNA methylation. Further analysis revealed that both DNA methylation and H3K27me3 have an effect on the expression of imprinted genes. Consistent with human, analysis of H3K27me3 showed that H3K27me3 undergoes reprogramming in pre-implantation. Thus, our data provides a genome-wide view of genomic imprinting in non-human primates and sheds light on the further understanding of epigenetic programming process of monkey.
2025-12-22 | GSE180569 | GEO
Project description:Genomic imprinting resulted by asymmetric epigenome of parents is a conserved phenomenon restricting biased expression of genes on two alleles. Disorder of imprinting can cause severe defects and diseases. In mouse and human, most of imprinted genes are expressed in species-specific and tissue-specific style. Here, rhesus monkeys as non-human primates are used to investigate primate genomic imprinting. We got a novel candidate canonical imprinted genes list in genome-wide by integrated analysis of allele-specific DNase I hypersensitive sites, differential expressed genes and differential DNA methylation. Further analysis revealed that both DNA methylation and H3K27me3 have an effect on the expression of imprinted genes. Consistent with human, analysis of H3K27me3 showed that H3K27me3 undergoes reprogramming in pre-implantation. Thus, our data provides a genome-wide view of genomic imprinting in non-human primates and sheds light on the further understanding of epigenetic programming process of monkey.
2025-12-22 | GSE180570 | GEO
Project description:This SuperSeries is composed of the SubSeries listed below.
2021-03-02 | GSE152106 | GEO
Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
2013-12-02 | E-GEOD-49764 | biostudies-arrayexpress
Project description:This SuperSeries is composed of the SubSeries listed below.
2018-06-27 | GSE112546 | GEO
Project description:There is evidence that expression and methylation of the imprinted paternally expressed gene 1/mesoderm-specific transcript homologue (PEG1/MEST) gene may be affected by assisted reproductive technologies (ARTs) and infertility. In this study, we sought to assess the imprinting status of the MEST gene in a large cohort of in vitro-derived human preimplantation embryos, in order to characterise potentially adverse effects of ART and infertility on this locus in early human development. Embryonic genomic DNA from morula or blastocyst stage embryos was screened for a transcribed AflIII polymorphism in MEST and imprinting analysis was then performed in cDNA libraries derived from these embryos. In 10 heterozygous embryos, MEST expression was monoallelic in seven embryos, predominantly monoallelic in two embryos, and biallelic in one embryo. Screening of cDNA derived from 61 additional human preimplantation embryos, for which DNA for genotyping was unavailable, identified eight embryos with expression originating from both alleles (biallelic or predominantly monoallelic). In some embryos, therefore, the onset of imprinted MEST expression occurs during late preimplantation development. Variability in MEST imprinting was observed in both in vitro fertilization and intracytoplasmic sperm injection-derived embryos. Biallelic or predominantly monoallelic MEST expression was not associated with any one cause of infertility. Characterisation of the main MEST isoforms revealed that isoform 2 was detected in early development and was itself variably imprinted between embryos. To our knowledge, this report constitutes the largest expression study to date of genomic imprinting in human preimplantation embryos and reveals that for some imprinted genes, contrasting imprinting states exist between embryos.
| S-EPMC3522198 | biostudies-other
Project description:This SuperSeries is composed of the SubSeries listed below.
2013-12-02 | GSE49764 | GEO
Project description:This SuperSeries is composed of the SubSeries listed below.
2019-05-01 | GSE112835 | GEO