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Mettl3 regulates late-stage retinogenesis and mouse retina m6A epitranscriptome

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE180815 | GEO | 2022/12/02

REPOSITORIES: GEO

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Mettl3 regulates late-stage retinogenesis

Project description:To study the function of Mettl3 during retinal development, we used Six3-Cre and Mettl3floxed mice to conditionally knock out Mettl3 from retinal progenitor cells. The mutant mice show defects in late-stage retinogenesis and structural and physiological homeostasis of the retina.

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Project description:m6A epitranscriptome of postnatal day 6 mouse retina was sequenced using MeRIP-seq.

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