Deciphering epigenetic and transcriptional alterations after Kmt2c/2d knock-out in mouse bladder urothelial cells

ABSTRACT: KMT2C and KMT2D are two of the most frequently mutated genes in histologically normal human bladder urothelium. In this study, we sought to model Kmt2c/d LOF mutations and investigate the biological mechanism of Kmt2c/d LOF mutations in bladder cancer development.

ORGANISM(S): Mus musculus

PROVIDER: GSE180947 | GEO | 2024/08/09

REPOSITORIES: GEO