Genomics

Dataset Information

25

Distribution of PcG, TrxG, RNA Pol II and associated histone marks in ML-DmBG3-c2 cells


ABSTRACT: PcG and TrxG are important epigenetic regulators of genome expression. Here we have determined genomic distributions of PC, E(Z), H3K27me3, TRX, ASH1, RNA Pol II, H3K4me3, H3K27ac in cultured Drosophila ML-DmBG3-c2 cells by hybridization of ChIP products with tiling microarrays. Overall design: genomic distributions of PC, E(Z), H3K27me3, TRX, ASH1, RNA Pol II, H3K4me3, H3K27ac in cultured Drosophila ML-DmBG3-c2 cells by hybridization of ChIP products with tiling microarrays

INSTRUMENT(S): [Dm35b_MR] Affymetrix Drosophila Tiling 1.0R Array

SUBMITTER: Yuri B Schwartz  

PROVIDER: GSE18100 | GEO | 2010-01-08

SECONDARY ACCESSION(S): PRJNA119389

REPOSITORIES: GEO

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Publications

Alternative epigenetic chromatin states of polycomb target genes.

Schwartz Yuri B YB   Kahn Tatyana G TG   Stenberg Per P   Ohno Katsuhito K   Bourgon Richard R   Pirrotta Vincenzo V  

PLoS genetics 20100108 1


Polycomb (PcG) regulation has been thought to produce stable long-term gene silencing. Genomic analyses in Drosophila and mammals, however, have shown that it targets many genes, which can switch state during development. Genetic evidence indicates that critical for the active state of PcG target genes are the histone methyltransferases Trithorax (TRX) and ASH1. Here we analyze the repertoire of alternative states in which PcG target genes are found in different Drosophila cell lines and the rol  ...[more]

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