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Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C (ATAC-Seq)

ABSTRACT: In this experiment, the effect of reduced CDX2 expression on chromatin accessibility in trophoblast stem cells (TSCs) was assayed using ATAC-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE181053 | GEO | 2022/07/01

REPOSITORIES: GEO

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Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C (RNA-Seq)

Project description:In this experiment, the effect of reduced CDX2 expression on the trophoblast stem cells (TSCs) transcriptome was assayed.

2022-07-01 | GSE181056 | GEO

Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C (ChIP-Seq)

Project description:In this experiment, the binding of CDX2 to chromatin in trophoblast stem cells was assayed using ChIP-seq.

2022-07-01 | GSE181055 | GEO

Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C

Project description:Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C

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Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C (ATAC-Seq)

Project description:Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C (ATAC-Seq)

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Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C (ChIP-Seq)

Project description:Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C (ChIP-Seq)

| PRJNA750478 | ENA

Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C (RNA-Seq)

Project description:Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C (RNA-Seq)

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Loss of Cdx2 drives direct trophoblast differentiation into trophoblast giant cells via TFAP2C

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-07-01 | GSE181058 | GEO

ChIP-seq anlysis of Sox2, Tfap2c, and Cdx2 in trophoblast stem cells.

2014-01-03 | GSE51511 | GEO

ChIP-seq anlysis of Sox2, Tfap2c, and Cdx2 in trophoblast stem cells.

Project description:To understand the mechanism underlying the transcriptional regulation by Sox2, we analyzed genome-wide binding sites of Sox2, Tfap2c, and Cdx2 in trophoblast stem (TS) cells by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq). ZHBTc4- and embryo-derived TS cell lines were maintained in the presence of FGF4 and mouse embryonic fibroblasts (MEFs).

2014-01-03 | E-GEOD-51511 | biostudies-arrayexpress

Gata3 acts alongside Cdx2 to promote trophoblast gene expression downstream of Tead4 during mouse development

Project description:The first lineage decisions during mouse development lead to establishment of embryonic and extraembryonic tissues. The transcription factor Cdx2 plays a central role by repressing pluripotency genes, such as Oct4 and promoting trophoblast fate at the blastocyst stage. Here we show that the transcription factor Gata3 is coexpressed with Cdx2 in the blastocyst and that overexpression of Gata3 in embryonic stem cells is sufficient to induce expression of trophoblast genes. Gata3 expression in the blastocyst does not depend on Cdx2, nor do Gata3 overexpressing cell lines require Cdx2 for expression of a subset of trophoblast genes. In the embryo, expression of Gata3, like Cdx2, depends on Tead4, and expression of both factors becomes restricted to nascent trophoblast by an Oct4-independent mechanism. These observations place Tead4 at the top of a trophoblast hierarchy, with Gata3 and Cdx2 acting downstream to induce expression of common and independent targets in this lineage. This SuperSeries is composed of the following subset Series: GSE12985: Differentiation time course of trophoblast stem cells GSE12986: Expression of Cdx2 or Gata3 in R1 mouse embryonic stem cells

2010-02-21 | E-GEOD-12999 | biostudies-arrayexpress

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