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Vessel Forming Mesenchymal Stromal Cell Populations

ABSTRACT: We have identified two vessel forming mesenchymal stromal cell populations. Population 1 (P1) is CD45-Ter119-Tie2+PDGFRa-CD31+CD105highSca1low and gives rise to stunted vessels (incomplete tubular structures) in a transplant setting, and Population 2 (P2) which is CD45-Ter119-Tie2+PDGFRa+CD31-CD105lowSca1high and forms stunted vessels and fat. To test the homogeneity and signal interactions of these populations we performed 10X single cell RNA-sequencing on them.

ORGANISM(S): Mus musculus

PROVIDER: GSE181177 | GEO | 2023/02/18

REPOSITORIES: GEO

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