Anti-CD4 treatment affects TCR repertoire of CD8+ T cells

ABSTRACT: Anti-CD4 monoclonal antibody, a prominent immunomodulatory agent, elicits robust anti-tumor immunity in various cancers by increasing tumor-infiltrating lymphocytes and promoting CD8+ T cell reactivity against tumor cell-derived antigens. We conducted TCR repertoire analysis of anti-CD4-exposed endogenous CD8+ T cells to investigate the expansion pattern of the cell population.

ORGANISM(S): Mus musculus

PROVIDER: GSE181280 | GEO | 2021/08/03

REPOSITORIES: GEO