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Transcriptomics of hypothalamic core areas suprachiasmatic nucleus and paraventricular nucleus of the short photoperiod adapted Djungarian Hamster during spontaneous daily torpor entry and normothermia using a de novo assembly of transcriptomes

ABSTRACT: Transcriptome analyses were performed to further disentangle hypothalamic control of spontaneous daily torpor and seasonal adaptation, concentrating on the most extreme metabolic and seasonal states of the Djungarian hamster (Phodopus sungorus). The data must be interpreted with respect to the metabolic and seasonal context, as described in the manuscript of the original research.

ORGANISM(S): Phodopus sungorus

PROVIDER: GSE181298 | GEO | 2026/06/24

REPOSITORIES: GEO

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Transcriptomics of hypothalamic core areas suprachiasmatic nucleus and paraventricular nucleus during spontanous daily torpor arousal in the Djungarian hamster (Phodopus sungorus).

Project description:Transcriptome analyses were performed to further disentangle hypothalamic control of spontaneous daily torpor in the Djungarian Hamster (Phodopus sungorus) acclimated to winter-like short photoperiod (SP). Samples of hypothalamic core areas suprachiasmatic nucleus (SCN) and paraventricular nucleus (PVN) were taken about seven hours after lights on (ZT07). After a de novo assembly of transcriptomes and a mapping against RefSeq of the house mouse (Mus musculus), data from hamsters sampled with hypothermic (HT) core body temperature during torpor arousal on a torpor-day (TD) were compared with data from hamsters sampled with normothermic (NT) core body temperature on a torpor-free day (TFD). The data must be interpreted with respect to the metabolic and seasonal context, as described in the manuscript of the original research.

2026-06-24 | GSE214011 | GEO

Transcriptomics of the Djungarian Hamster Hypothalamus

Project description:Transcriptome analyses were performed to further disentangle hypothalamic control of spontaneous daily torpor and seasonal adaptation, concentrating on the most extreme metabolic and seasonal states of the Djungarian hamster (Phodopus sungorus). The data must be interpreted with respect to the metabolic and seasonal context, as described in the manuscript of the original research.

2021-12-29 | GSE179663 | GEO

The transcriptional cortical adaptations to daily torpor in Phodopus sungorus

Project description:Torpor is an essential evolutionary strategy that allows mammals to conserve resources under extreme environmental conditions. While the hypothalamus is a key regulator of systemic adaptations to energy scarcity and reduced temperature, it remains unclear how the cortex, with its high metabolic demand, endures this state. Here, we performed RNA sequencing on neuronal and non-neuronal nuclei isolated from the cortex of Djungarian hamsters (Phodopus sungorus) across different seasonal and metabolic states. We found that non-neuronal cells primarily adapt during the seasonal transition from summer to winter phenotype, with differential expression of genes linked to circadian rhythm. In contrast, cortical neurons exhibited major transcriptional changes only between normothermia and hypothermia, marked by increased expression of RNA catabolic pathways. Finally, comparison with published hypothalamic datasets revealed distinct transcriptional programs between the cortex and hypothalamus. Together, these findings highlight cell type- and region-specific adaptations that preserve CNS integrity during metabolic depression.

2026-06-01 | GSE320478 | GEO

Transcriptomics of hypothalamic core areas suprachiasmatic nucleus and paraventricular nucleus during spontanous daily torpor arousal in the Djungarian hamster (Phodopus sungorus).

Project description:Transcriptomics of hypothalamic core areas suprachiasmatic nucleus and paraventricular nucleus during spontanous daily torpor arousal in the Djungarian hamster (Phodopus sungorus).

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The transcriptional cortical adaptations to daily torpor in Phodopus sungorus

Project description:The transcriptional cortical adaptations to daily torpor in Phodopus sungorus

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Comparative transcriptomics across photoperiod in the Siberian hamster and Japanese quail brains

Project description:Seasonal morphological brain plasticity plays a key role in driving adaptive behavioural responses. Structural changes in the brain including the hippocampus and amygdala (nucleus taeniae in birds), across photoperiods are thought to underlie seasonal shifts in emotional state. For humans, this includes manifestations of short photoperiod seasonal affective disorder (SAD). While morphological brain changes are well documented, the associated transcriptomic dynamics remain poorly understood. Here, we examined the transcriptomes of the hippocampus and amygdala or nucleus taeniae in two highly photoperiodic species, the Siberian hamster (Phodopus sungorus) and the Japanese quail (Coturnix japonica), to identify transcriptomic changes underpinning seasonal shifts in emotional state. Hamsters and quail exhibited robust physiological changes between long and short photoperiod treatment. Under short photoperiod, hamsters displayed anxiety-like behaviour (increased grooming) in the open field test, consistent with a SAD-like phenotype. Transcriptomic analysis of the amygdala in hamsters identified 76 significantly differentially expressed (DE) transcripts (including transthyretin, TTR) and prolactin receptor, PRLR as differentially expressed, but not significantly. In the quail nucleus taeniae, we found 54 DE transcripts (including tenascin-C, TNC). In the hamster hippocampus, 14 DE transcripts were found, including mahogunin ring finger-1 (MGRN1), and 31 in the quail hippocampus, including eyes absent-2 (Eya2). These findings provide novel insights into the transcriptomic mechanisms underpinning seasonal affective states and suggest conserved roles for prolactin and thyroid hormone signalling in mediating seasonal changes in physiology and affective behaviour, particularly in the Siberian hamster.

2025-06-23 | GSE300190 | GEO

Transcriptomics of hypothalamic core areas suprachiasmatic nucleus and paraventricular nucleus of the short photoperiod adapted Djungarian Hamster during spontaneous daily torpor entry and normothermia using a de novo assembly of transcriptomes

Project description:Transcriptomics of hypothalamic core areas suprachiasmatic nucleus and paraventricular nucleus of the short photoperiod adapted Djungarian Hamster during spontaneous daily torpor entry and normothermia using a de novo assembly of transcriptomes

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Comparative transcriptomics of the garden dormouse hypothalamus during early torpor, late torpor and interbout arousal of hibernation

Project description:Comparative transcriptomics of the garden dormouse hypothalamus during early torpor, late torpor and interbout arousal of hibernation

2023-11-13 | GSE207494 | GEO

Neurons that regulate mouse torpor

Project description:The advent of endothermy more than a hundred million years ago is thought to have been a defining feature of mammalian and avian evolution, achieved through continuous fine-tuned homeostatic regulation of core body temperature and metabolism. However, when challenged by food deprivation or harsh environmental conditions, many mammalian species initiate adaptive energy-conserving survival strategies, including torpor and hibernation, during which their core body temperature decreases far below its homeostatic setpoint. How homeothermic mammals initiate and regulate these extraordinary hypothermic states remains largely unknown. Here, we discover that entry into mouse torpor, a fasting-induced state with greatly decreased metabolic rate and body temperature as low as 20°C, is regulated by a population of neurons in the preoptic area of the hypothalamus. We show that re-stimulation of neurons activated during a previous bout of torpor is sufficient to initiate torpor, even in animals that are not calorically restricted. We localize these torpor-regulating neurons to the anteroventral medial and lateral preoptic area and molecularly identify a population of glutamatergic Adcyap1+ neurons whose activity accurately determines when calorically-restricted animals naturally initiate and exit torpor, and whose inhibition disrupts the natural process of torpor entry, maintenance and arousal. Taken together, we discover a specific hypothalamic neuronal subpopulation in the mouse brain that serves as a core regulator of torpor. This work forms the basis for future explorations of mechanisms and circuitry regulating extreme hypothermic and hypometabolic states, enabling genetic access to monitor, initiate, manipulate and study these ancient adaptations of homeotherm biology.

2020-04-30 | GSE149344 | GEO

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