Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Placenta transcriptomics of Mbnl2 and Mbnl3 KOs (RNA-seq)

ABSTRACT: To investigate the impact of Mbnl2 and Mbnl3 in placenta development and function, we have generated RNA-seq data from placenta from single and double KO mice at different developmental stages.

ORGANISM(S): Mus musculus

PROVIDER: GSE181320 | GEO | 2022/07/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

3' sequencing of placenta form Mbnl2 and Mbnl3 KOs

Project description:To investigate the impact of Mbnl2 and Mbnl3 in placenta development and function through the regulation of alternative poly-adenylation, we have generated 3'-seq data from placenta from single and double KO mice at different developmental stages.

2022-07-01 | GSE181326 | GEO

Placenta transcriptomics of Mbnl2 and Mbnl3 KOs (RNA-seq)

Project description:Placenta transcriptomics of Mbnl2 and Mbnl3 KOs (RNA-seq)

| PRJNA751567 | ENA

3' sequencing of placenta form Mbnl2 and Mbnl3 KOs

Project description:3' sequencing of placenta form Mbnl2 and Mbnl3 KOs

| PRJNA751580 | ENA

Functional and evolutionary impact of Mbnl2 and Mbnl3 genes in eutherian placenta

Project description:Functional and evolutionary impact of Mbnl2 and Mbnl3 genes in eutherian placenta

| PRJNA751590 | ENA

MBNL2 knockdown in hypoxic breast cancer cells

Project description:The transcriptome-wide response of hypoxic breast cancer cells upon MBNL2 knockdown was analyzed. Differential gene expression and alternative splicing were investigated.

2020-04-21 | GSE136231 | GEO

Modulation of ESRP2 and MBNL2 in normal kidney and clear cell renal cell carcinoma cell lines for analysis of stability programs

Project description:While analyzing mRNA expression profiles of clear cell renal cell carcinoma (ccRCC) tumors, we found that the mRNAs that are bound at their 3' UTRs by muscleblind-like splicing regulator 2 (Mbnl2) and epithelial splicing regulatory protein 2 (ESRP2) are up-regulated in tumor compared to patient-matched normal tissues. Given that MBNL2 increases the stability of its targets and ESRP2 destabilizes its targets, we predicted that, in ccRCC tumors, MBNL2 activity increases, while ESRP2 activity decreases. To investigate the effect of each of these two RNA-binding proteins (RBPs) on the transcriptome of the cell, we used shRNA to knockdown MBNL2 in two different cell line models of ccRCC (786-O and A-498), and also to knockdown ESRP2 in normal primary renal proximal tubule epithelial cells (PRPTEC). RNA-seq revealed that MBNL2 knockdown partially reverses the ccRCC-associated transcriptome in ccRCC cell lines, whereas ESRP2 knockdown shifts the transcriptome of PRPTEC toward that of ccRCC.

2018-03-23 | GSE83999 | GEO

MBNL2 knockdown in hypoxic breast cancer cells

Project description:MBNL2 knockdown in hypoxic breast cancer cells

| PRJNA561706 | ENA

Gene expression in E18.5 Tex19.1-/- mouse placenta

Project description:Microarray experiment to identify changes in gene expression in 18.5 day post coitum Tex19.1-/- mouse placenta. Tex19.1 is expressed in trophectoderm-derived cells in the placenta. Tex19.1-/- placentas are small and have defects in junctional zone and labyrinth layers of the placenta, Tex19.1-/- embryos exhibit intra-uterine growth retardation. Data provides insight into the changes in gene expression and cell composition in Tex19.1-/- placentas. Six E18.5 Tex19.1-/- placentas (KO: four XX, two XY), four E18.5 Tex19.1+/- littermate control placentas (HET: four XX), and two E18.5 Tex19.1+/+ littermate control placentas (WT: two XY) are included in the analysis.

2013-03-08 | E-GEOD-41823 | biostudies-arrayexpress

Mouse Placenta Proteome and Phosphoproteome

Project description:TMT based quantification of protein abundance and phosphorylation state for developing mouse placenta. Timed-pregnant CD-1 mice were obtained from Charles Rivers Labs and dissected at e7.5 to extract the ectoplacental cones (EPCs) and at e9.5 to obtain the placenta as described by Martin and Cockroft (Martin, P.; Cockroft, D. L. Culture of Postimplantation Mouse Embryos). Staging of the mouse embryos was done according to Theiler criteria (Theiler, K. The House Mouse: Development and Normal Stages from Fertilization to 4 Weeks of Age; Springer-Verlag, 1972.)

2018-08-24 | MSV000082849 | MassIVE

Mbnl2 loss alters novel context processing and impairs object recognition memory

Project description:Myotonic dystrophy type I (DM1) patients demonstrate visuospatial dysfunction and impaired performance in tasks requiring recognition or memory of figures and objects. In DM1, CUG expansion RNAs inactivate the Muscleblind-like (MBNL) proteins. We show that constitutive Mbnl2 inactivation in Mbnl2ΔE2/ΔE2 mice, selectively impairs object recognition memory in the novel object recognition test. When exploring the context of a novel arena in which the objects are later encountered, the Mbnl2ΔE2/ΔE2 dorsal hippocampus responds with a lack of enrichment for learning and memory related pathways, mounting instead transcriptome alterations predicted to impair growth and neuron viability. In Mbnl2ΔE2/ΔE2 mice, saturation effects may prevent deployment of a functionally relevant transcriptome response during novel context exploration. Post-novel context exploration alterations in genes implicated in tauopathy and dementia are observed in the Mbnl2ΔE2/ΔE2 dorsal hippocampus. Thus MBNL2 inactivation in DM1 patients may alter novel context processing in the dorsal hippocampus and impair object recognition memory.

2023-05-22 | GSE226191 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data