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Inhibition of pyrimidine biosynthesis targets protein translation in AML [ATAC-seq_MN-2]

ABSTRACT: Investigation of the chromatin accessibility in MN cells. Mice bearing MN tumors were treated with AG636 for 2 days. Leukemic stem cells (cKit high; CD11b low) from bone marrow and spleen were isolated. RNA sequencing and ATAC-seq were performed.

ORGANISM(S): Mus musculus

PROVIDER: GSE181660 | GEO | 2022/04/26

REPOSITORIES: GEO

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Inhibition of pyrimidine biosynthesis targets protein translation in AML [RNA-seq_MN-2]

Project description:Investigation of the transcriptional profile and compared with the genome accessibility (using ATAC-seq) in MN cells. Mice bearing MN tumors were treated with AG636 for 2 days. Leukemic stem cells (cKit high; CD11b low) from bone marrow and spleen were isolated. RNA sequencing and ATAC-seq were performed.

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