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CTCF acetylation at lysine 20 is required for early cardiac mesoderm differentiation from embryonic stem cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE181705 | GEO | 2022/10/24

REPOSITORIES: GEO

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CTCF acetylation at lysine 20 is required for early cardiac mesoderm differentiation from embryonic stem cells [ATAC-Seq]

Project description:In this study, we show that CTCF could be acetylated at lysine 20 (CTCF-K20) by CREB binding protein (CBP) and deacetylated by HDAC6, respectively. CTCF-K20 is required for CTCF interacting with CBP. CTCF point mutation at K20 has no effect on self-renewal but blocks mesoderm differentiation of mouse embryonic stem cells (mESCs).

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