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Transcriptome comparison between Zbtb46-deficient and -sufficient group 3 innate lymphoid cells

ABSTRACT: We unexpectedly identify one unique subset of group 3 innate lymphoid cells (ILC3s) that co-expresses Zbtb46, a transcription factor that specifies conventional dendritic cells (cDCs). Zbtb46 is robustly expressed by CCR6+ lymphoid tissue inducer (LTi)-like ILC3s that are developmentally and phenotypically distinct from cDCs. To determine the function of Zbtb46 in ILC3s, we performed RNA sequencing on CCR6+ ILC3s sorted from the large intestine of Zbtb46 f/f and Rorc Cre Zbtb46 f/f mice at steady state.

ORGANISM(S): Mus musculus

PROVIDER: GSE181865 | GEO | 2022/05/02

REPOSITORIES: GEO

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