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Pluripotency-Independent Induction of Human Trophoblast Stem Cells from Fibroblasts [RNA-Seq]

ABSTRACT: Transcription profile analysis revealed similarity/dissimilarity between human blastocyst derived trophoblast stem cells (hbdTSCss), human induced trophoblast stem cells (hiTSCs), human foreskin fibroblasts (HFFs) and pluripotent stem cells (hESCs, hiPSCs)

ORGANISM(S): Homo sapiens

PROVIDER: GSE182014 | GEO | 2023/02/21

REPOSITORIES: GEO

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Pluripotency-Independent Induction of Human Trophoblast Stem Cells from Fibroblasts [RRBS]

Project description:RRBS analysis revealed similarity/dissimilarity between human blastocyst derived trophoblast stem cells (hbdTSCs), human induced trophoblast stem cells (hiTSCs), human foreskin fibroblasts (HFFs) and pluripotent stem cells (hESCs, hiPSCs)

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Project description:We explored the trophoblast differentiation model using human induced pluripotent stem cells (hiPSCs) to gain new insights into the early development of human placenta. In our previous study, we have optimized culture conditions for hiPSC-derived trophoblasts. To identify the characteristics of trophoblast lineage cells derived from BMP4-treated hiPSCs, we collected cells using a pan-trophoblast marker, KRT7, with flow cytometry and performed comprehensive gene expression analysis.

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