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Allergens Elicit an Antiviral Signature in Dendritic Cells

ABSTRACT: This study compares the transcriptomic changes induced by three distinct aeroallergens in a dendritic cell line with the goal of finding similarities in the response at the gene expression level. Using RNA sequencing of DC2.4 cells, we find that house dust mite, cat hair and timothy grass allergen extracts all induce what appears to be an antiviral genetic signature despite the lack of any viral components in each allergen. Such information may be useful in trying to design therapeutics or interventions for allergic responses which could be effective for multiple allergens despite differences in source and structure.

ORGANISM(S): Mus musculus

PROVIDER: GSE182277 | GEO | 2021/08/20

REPOSITORIES: GEO

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