Runx3 drives a tissue-residency program that is absent in CD4+ T cells [RNA-seq]

ABSTRACT: Pattens of tissue-residency differs between CD4+ and CD8+ memory T cells in evironmentally exposed organs. The lineage-controlling transcription factor Runx3, expressed in CD8+ T cells, is responsible for shaping a tissue-resident gene network in response to the cytokine TGF-b. While the lack of Runx3 by CD4+ T cells precludes these transcriptional changes, Runx3-overexpression in CD+ T cells enable phenotypical, transcriptional and functional changes to allow residency.

ORGANISM(S): Mus musculus

PROVIDER: GSE182511 | GEO | 2022/05/24

REPOSITORIES: GEO