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Dataset Information

24

Somatic mutations in p85α promote tumorigenesis through p110α activation


ABSTRACT: Frequent mutations in the regulatory p85a subunit (PIK3R1 gene) were identified in colon cancer and shown to promote cell survival, Akt activation, anchorage independent cell growth and oncogenesis. A number of tumor samples including colon, breast, NSCLC and gastric were also profiled for co-occurrence of chromosomal copy number changes including gene amplifications in PI3K pathway on Affymterix 100K SNP arrays. Overall design: Analysis of copy number changes in several different tumor types

INSTRUMENT(S): [Mapping50K_Hind240] Affymetrix Human Mapping 50K Hind240 SNP Array

ORGANISM(S): Homo sapiens  

SUBMITTER: Zhengyan Kan 

PROVIDER: GSE18252 | GEO | 2009-10-01

SECONDARY ACCESSION(S): PRJNA119591

REPOSITORIES: GEO

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