Somatic mutations in p85α promote tumorigenesis through p110α activation

ABSTRACT: Frequent mutations in the regulatory p85a subunit (PIK3R1 gene) were identified in colon cancer and shown to promote cell survival, Akt activation, anchorage independent cell growth and oncogenesis. A number of tumor samples including colon, breast, NSCLC and gastric were also profiled for co-occurrence of chromosomal copy number changes including gene amplifications in PI3K pathway on Affymterix 100K SNP arrays.

ORGANISM(S): Homo sapiens

PROVIDER: GSE18252 | GEO | 2009/10/01

SECONDARY ACCESSION(S): PRJNA119591

REPOSITORIES: GEO