Genomics

Dataset Information

0

Somatic mutations in p85α promote tumorigenesis through p110α activation


ABSTRACT: Frequent mutations in the regulatory p85a subunit (PIK3R1 gene) were identified in colon cancer and shown to promote cell survival, Akt activation, anchorage independent cell growth and oncogenesis. A number of tumor samples including colon, breast, NSCLC and gastric were also profiled for co-occurrence of chromosomal copy number changes including gene amplifications in PI3K pathway on Affymterix 100K SNP arrays.

ORGANISM(S): Homo sapiens

PROVIDER: GSE18252 | GEO | 2009/10/01

SECONDARY ACCESSION(S): PRJNA119591

REPOSITORIES: GEO

Similar Datasets

2009-10-10 | E-GEOD-18252 | biostudies-arrayexpress
2012-01-19 | GSE34957 | GEO
2012-01-19 | E-GEOD-34957 | biostudies-arrayexpress
2013-01-10 | E-GEOD-39793 | biostudies-arrayexpress
2010-12-16 | GSE26075 | GEO
2011-08-22 | GSE12370 | GEO
2009-09-15 | GSE17429 | GEO
2013-01-10 | GSE39793 | GEO
2010-04-06 | E-GEOD-14437 | biostudies-arrayexpress
2012-09-04 | E-GEOD-36459 | biostudies-arrayexpress