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Expression (Gene) in the endothelial cells of the mouse male prefrontal cortex (PFC) following 10-day chronic social stress exposure [male CSDS]

ABSTRACT: Cell-specific transcriptomic analysis were performed on PFC endothelial cells of unstressed controls (CTRL), stress-susceptible (SS) and resilient (RES) mice to identify novel genes and pathways involved in stress responses

ORGANISM(S): Mus musculus

PROVIDER: GSE182671 | GEO | 2021/10/29

REPOSITORIES: GEO

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Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 10-day chronic social stress exposure [Female_CSDS]

Project description:Cell-specific transcriptomic analysis were performed on PFC endothelial cells of unstressed controls (CTRL), stress-susceptible (SS) and resilient (RES) mice to identify novel genes and pathways involved in stress responses

2021-10-29 | GSE173794 | GEO

Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 10-day chronic social stress or 6-day subchronic variable stress exposure [Female_CSDS_vs_SCVS]

2021-10-29 | GSE173796 | GEO

Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 10-day chronic social stress or 6-day subchronic variable stress exposure was compared to male [Male_SS_vs_Female_SS_or_SCVS]

Project description:Cell-specific transcriptomic analysis were performed on PFC endothelial cells of stress-susceptible (SS) and resilient (RES) mice along with females subjected to 6 days of subchronic variable stress to identify novel genes and pathways involved in stress responses. These gene lists were compared to published findings obtained in the male NAc following 10 days of chronic social stress exposure (Dudek et al., 2020)

2021-10-29 | GSE173797 | GEO

Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 6-day subchronic variable stress (SCVS) exposure [Female_SCVS]

Project description:Cell-specific transcriptomic analysis were performed on PFC endothelial cells of unstressed controls (CTRL) and mice exposed to SCVS to identify novel genes and pathways involved in stress responses

2021-10-29 | GSE173795 | GEO

RNAseq anaysis of hippocamal parvalbumin-positive interneurons in mice exposed to chronic social defat stress

Project description:Purpose: To identify genes differentially expressed in parvalbumin-positive (PV) interneurons of the hippocampus in non-defetaed (CTRL), stress-susceptible and stress-resilient mice. Method: Translating Ribosome Affinity Purification (TRAP) to isolate RNA from PV+ cells, cDNA synthesis and next generation RNAseq using Illumina Nextseq 500 sequencer. Results: RNA-seq revealed 458 DEGs between non-defeated and resilient mice, 1976 DEGs in non-defeated and susceptible mice, and 3475 DEGs in resilient and susceptible mice.

2021-09-14 | GSE184027 | GEO

DNA Methyltransferase 3A Mediates the Sustained Effects of Stress on Synaptic Functions and Behaviors [RRBS]

Project description:Emerging evidence suggests that epigenetic mechanisms regulate aberrant gene transcription in stress-associated mental disorders. However, it remains to be elucidated about the role of DNA methylation and its catalyzing enzymes, DNA methyltransferases (DNMTs), in this process. Here we found that rats exposed to chronic (2-week) unpredictable stress exhibited a substantial reduction of Dnmt3a after stress cessation in the prefrontal cortex (PFC), a key target region of stress. Treatment of unstressed control rats with DNMT inhibitors recapitulated the effect of chronic unpredictable stress on decreased AMPAR expression and function in PFC. In contrast, overexpression of Dnmt3a in PFC of stressed animals prevented the loss of glutamatergic responses. Moreover, the stress-induced behavioral abnormalities, including the impaired recognition memory and aggressive behaviors, were ameliorated by Dnmt3a expression in PFC of stressed animals. Lastly, we found genome-wide DNA methylation changes in PFC of stressed rats are selectively enriched at several pathways, such as axon guidance, Wnt signaling and neurotransmission. These findings have therefore recognized the role of DNA epigenetic modification in stress-induced disturbance of synaptic functions and cognitive & emotional processes.

2020-12-31 | GSE147846 | GEO

DNA Methyltransferase 3A Mediates the Sustained Effects of Stress on Synaptic Functions and Behaviors [RNA-seq]

2020-12-31 | GSE147845 | GEO

Effect of Adolescent Stress on PFC miRNA Gene Expression

Project description:Effect of Adolescent Stress on PFC miRNA Gene Expression

| PRJNA721960 | ENA

Synaptosome Proteomics, Fraction 2

Project description:Synaptosomes were isolated by Percoll gradient centrigation and iTRAQ based nanoLC-MS/MS proteomics. Three synapse fractions were studied from three kind of experimental rat groups namely, stressed with anhedonia, stress resilient and unstressed controls.

2016-04-26 | PXD001775 | Pride

Synaptosome Proteomics, Fraction 3

2016-04-27 | PXD001776 | Pride

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