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Expression data from germinal center (GC) B cells of Tnfrsf13B wild type, knockout and A144E mutant mice 10 days post immunization with allogenic cells

ABSTRACT: B cells in the germinal center of the spleen produce antibodies in responses to different antigens. Tnfrsf13b knockout and A144E mice can underlie more aggressive B cells effector responses, possibly at the cost of inadvertent pathogenicity; however, neither the amplitude nor the pathogenicity are simple functions of the amount of antigen-specific IgG produced. We used microarrays to detail the global program of gene expression of germinal center B cells and identified distinct classes of up-regulated genes in the different strains of mice with Tnfrsf13b wild type, knockout, monoallilic or biallec A144E missense mutation.

ORGANISM(S): Mus musculus

PROVIDER: GSE182739 | GEO | 2021/08/26

REPOSITORIES: GEO

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