AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation [Hs]

ABSTRACT: We identified enrichment of a disease-enhancing, proinflammatory subpopulation of microglia in human AD patient brains with the R47H-TREM2 mutation, and uncovered that enhanced Akt signaling in microglia underlies the proinflammatory cytokine state and synaptic toxicity in our R47H-TREM2 tauopathy mouse model.

ORGANISM(S): Homo sapiens

PROVIDER: GSE183068 | GEO | 2022/01/07

REPOSITORIES: GEO