Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

ABSTRACT: FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

ORGANISM(S): Mus musculus

PROVIDER: GSE18308 | GEO | 2010/01/01

SECONDARY ACCESSION(S): PRJNA118039

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

Project description:FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis expression profile between six independant neural stem cell lines (three FoxO null and three wild type) were compared

2009-12-31 | E-GEOD-18308 | biostudies-arrayexpress

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.

Project description: Not available

| S-EPMC3285492 | biostudies-literature

Mus musculus

Project description:FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

| PRJNA118039 | ENA

MicroRNAs and their isomiRs function cooperatively to target common biological pathways

Project description:This SuperSeries is composed of the following subset Series: GSE29043: MicroRNAs and their isomiRs function cooperatively to target common biological pathways (Illumina expression beadchip) GSE29100: MicroRNAs and their isomiRs function cooperatively to target common biological pathways (Agilent miRNA array) Refer to individual Series This represents the miRNA placenta samples and mRNA + miRNA pulldown only The miRNA-Seq data have been submitted to the short read archive under SRA number SRP006043: http://www.ncbi.nlm.nih.gov/sra?term= SRP006043

2011-12-21 | E-GEOD-29101 | biostudies-arrayexpress

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.

Project description:Activated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3, and FoxO4, represent one of several effector arms of PI3K-AKT signaling, prompting genetic analysis of the role of FoxOs in the neoplastic phenotypes linked to PI3K-AKT activation. While germline or somatic deletion of up to five FoxO alleles produced remarkably modest neoplastic phenotypes, broad somatic deletion of all FoxOs engendered a progressive cancer-prone condition characterized by thymic lymphomas and hemangiomas, demonstrating that the mammalian FoxOs are indeed bona fide tumor suppressors. Transcriptome and promoter analyses of differentially affected endothelium identified direct FoxO targets and revealed that FoxO regulation of these targets in vivo is highly context-specific, even in the same cell type. Functional studies validated Sprouty2 and PBX1, among others, as FoxO-regulated mediators of endothelial cell morphogenesis and vascular homeostasis. Mice were engineered with negative control (MxCre- Fk1 L/L Fk2 L/L Afx L/L) and experimental (MxCre+ Fk1 L/L Fk2 L/L Afx L/L) genotypes. RNAs were isolated from Lung endothelial cells (2 negative controls, 2 experimental), liver sinusoidal endothelial cells (3 negative controls, 3 experimental) and thymus cells (2 negative controls, 2 experimental), and profiled on Affymetrix Mouse Genome 430 2.0 Array.

2011-03-16 | E-GEOD-27932 | biostudies-arrayexpress

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.

2011-03-16 | GSE27932 | GEO

Whole-genome screen identifies diverse pathways that negatively regulate ciliogenesis.

Project description: Not available

| S-EPMC8120696 | biostudies-literature

SOX4 AND SMARCA4 COOPERATIVELY REGULATE PI3K SIGNALING THROUGH TRANSCRIPTIONAL ACTIVATION OF TGFBR2 IN BASAL LIKE BREAST CANCER

Project description:Dysregulation of PI3K/Akt signaling is a dominant feature in basal-like or triple-negative breast cancers (TNBC). However, the mechanisms regulating this pathway are largely unknown in this subset of aggressive tumors. Here we demonstrate that the transcription factor SOX4 is a key regulator of PI3K signaling in TNBC. Genomic and proteomic analyses coupled with mechanistic studies identified TGFBR2 as a direct transcriptional target of SOX4 and demonstrated that TGFBR2 is required to mediate SOX4-dependent PI3K signaling. We further report that SOX4 and the SWI/SNF ATPase SMARCA4, which are uniformly overexpressed in basal-like tumors, form a previously unreported complex that is required to maintain an open chromatin conformation at the TGFBR2 regulatory regions in order to mediate TGFBR2 expression and PI3K signaling. Collectively, our findings delineate the mechanism by which SOX4 and SMARCA4 cooperatively regulate PI3K/Akt signaling and suggest that this complex may play an essential role in TNBC genesis and/or progression.

2021-03-02 | PXD022811 | Pride

Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development.

Project description: Not available

| S-EPMC3705565 | biostudies-literature

Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation.

Project description: Not available

| S-EPMC2878520 | biostudies-literature