Transcriptomics,Genomics

Dataset Information

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Role of YAP in Liver Regeneration After Acetaminophen Overdose


ABSTRACT: Overdose of acetaminophen (APAP) is the major cause of acute liver failure in the Western world with very limited treatment options. Previous studies from our groups and others have shown that timely activation of liver regeneration is a critical determinant of transplant-free survival of APAP-induced acute liver failure (ALF) patients. We used affy microarrays to explore the mechanisms of transcriptional expression in YAP-KO mice after 300mg/kg APAP overdose. Overall design: Livers were extracted from wildtype and YAP-KO male mice that were fasted for 0 hour time points. Intraperitoneal injection of 300 mg/kg acetaminophen overdose was given to fasted mice and livers were extracted 24 hours after overdose. RNA was extracted from 100 mg of liver tissue and pooled together (n of 3) to be used for microarray analysis.

INSTRUMENT(S): [MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CSV version]

ORGANISM(S): Mus musculus  

SUBMITTER: Dakota Robarts  

PROVIDER: GSE183119 | GEO | 2021-10-04

REPOSITORIES: GEO

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Publications

Hepatocyte-Specific Deletion of Yes-Associated Protein Improves Recovery From Acetaminophen-Induced Acute Liver Injury.

Poudel Samikshya S   Cabrera Diego Paine DP   Bhushan Bharat B   Manley Michael W MW   Gunewardena Sumedha S   Jaeschke Hartmut H   Apte Udayan U  

Toxicological sciences : an official journal of the Society of Toxicology 20211101 2


Overdose of acetaminophen (APAP) is the major cause of acute liver failure (ALF) in the Western world with very limited treatment options. Previous studies from our groups and others have shown that timely activation of liver regeneration is a critical determinant of transplant-free survival of APAP-induced ALF patients. Here, we report that hepatocyte-specific deletion of Yes-associated protein (Yap), the downstream mediator of the Hippo Kinase signaling pathway results in faster recovery from  ...[more]

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