Role of YAP in Liver Regeneration After Acetaminophen Overdose

ABSTRACT: Overdose of acetaminophen (APAP) is the major cause of acute liver failure in the Western world with very limited treatment options. Previous studies from our groups and others have shown that timely activation of liver regeneration is a critical determinant of transplant-free survival of APAP-induced acute liver failure (ALF) patients. We used affy microarrays to explore the mechanisms of transcriptional expression in YAP-KO mice after 300mg/kg APAP overdose.

ORGANISM(S): Mus musculus

PROVIDER: GSE183119 | GEO | 2021/10/04

REPOSITORIES: GEO