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Deciphering responses of the fetal suprachiasmatic nuclei to the rhythmic maternal signals using omics approach

ABSTRACT: We report circadian (time series, circadian time 0, 3, 6, 9, 12, 18, 21h) transcriptomic analysis of mouse fetal (embryonic day 17) suprachiasmatic nuclei (SCN) from either sham operarated ad libitum fed mothers (group A) or from SCN-lesioned mothers on resctricted feeding regime. The analysis revealed low amplitude rhythms in the fetal SCN driven by maternal SCN and/or maternal feeding behavior.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE183172 | GEO | 2022/04/01

REPOSITORIES: GEO

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Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus

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Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus

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Mouse SCN in LC-MSMS - The suprachiasmatic nucleus (SCN) acts as the central clock to coordinate circadian oscillations in mammalian behavior, physiology and gene expression. Despite our knowledge of the circadian transcriptome of the SCN, how it impacts genome-wide protein expression is not well understood. Here, we interrogated the murine SCN proteome across the circadian cycle using SILAC-based quantitative mass spectrometry.

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Astrocytes in the mouse suprachiasmatic nuclei respond directly to glucocorticoids feedback

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