Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation.

ABSTRACT: To investigate the transcriptional profile of human circulating T cells with skin tissue-resident memory phenotype (cTRM) in GVHD we performed bulk RNA sequencing from SMART-seq2 of sorted human cTRM (CD3+ CD4+ CLA+ CD103+) and conventional T cells (CD3+ CD4+ CD103-), and single cell RNA sequencing from 10X Genomics of sorted human CD45+, both from isolated blood PBMCs of patients with active acute GVHD.

ORGANISM(S): Homo sapiens

PROVIDER: GSE183212 | GEO | 2021/09/24

REPOSITORIES: GEO