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SHH is downstream of immediate early genes and is targeted by chemotherapy on a specific enhancer [CUT&Tag, ATAC-seq]

ABSTRACT: Sonic Hedgehog (SHH) signaling is a key regulator of embryonic development and tissue homeostasis, and is involved in gastrointestinal (GI) cancer progression. Here we show that SHH gene expression is down-regulated by chemotherapy drugs. The 139Kb upstream enhancer is specifically targeted by the immediate early gene EGR1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE183663 | GEO | 2021/12/31

REPOSITORIES: GEO

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SHH is downstream of immediate early genes and is targeted by chemotherapy on a specific enhancer [RNA-seq]

Project description:Sonic Hedgehog (SHH) signaling is a key regulator of embryonic development and tissue homeostasis, and is involved in gastrointestinal (GI) cancer progression. Here we show that SHH gene expression is down-regulated by chemotherapy drugs.

2021-12-31 | GSE183977 | GEO

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